With five wins and a draw this season, Bayern are behind only Borussia Dortmund on goal difference at the top of the table and they have plenty to celebrate with a visit to the city's beer festival planned after Saturday's encounter.
The Wolves have lost all three of their away games this season and arrive in Munich with defeat number four widely expected.
That could inspire them to create an upset, however, just over a year since Bayern lost their last Bundesliga game at home to Bayer Leverkusen in equally unexpected circumstances.
"Of course this is an attractive challenge," said Wolfsburg's director of sport Klaus Allofs.
"There is very little to lose for us.
"Even if the expectations of Wolfsburg in the general public are not particularly high, we have the ambition of playing a good game in Munich and if we are to be successful, we need to work as a team."
Allofs is adamant European champions Bayern will not take the visitors lightly.
"Bayern respect us, otherwise they would not have rotated their team against Hannover in midweek but would have instead waited to do so against us," added Allofs.
"You can win in any one game, and we have this hope."
Wolfsburg striker Ivica Olic does not believe his former club are unbeatable and says "now's the time" for him to get one over them.
"I've lost both my games against them with Wolfsburg," he said. "Why shouldn't we beat them now? Of course we need to be at our best, and of course we also need some luck."
Wolfsburg welcome another former Bayern player back into their side with Luiz Gustavo returning after his second suspension of the season while a former Wolf, Mario Mandzukic, should lead the Bayern attack.
There could also be a place in the Bayern squad for Mario Gotze, who is approaching full fitness again after a return to training following a three-week absence due to an ankle injury.