It had looked like the 22-year-old's career would never quite recover from a horrific double leg break sustained in a challenge with Stoke's Ryan Shawcross in February 2010.
But, after a few inconsistent seasons, Ramsey is now in the form of his life and on Wednesday evening played a key role in Arsenal's 2-1 win at the Stade Velodrome.
Having seen Theo Walcott open the scoring against the run of play, the Wales international struck home seven minutes from time put the game out of reach for the hosts.
Such is his form, that some have suggested there are few better midfielders in Europe right now.
"I don't know if anybody is playing better," Wenger said when asked about his current form. "For me, I don't look at it like that.
"Aaron is playing well and that is most important, so is that he continues to improve.
"I thought it would be a tricky game here tonight [Wednesday]. Before the game I was conscious Marseille would be well focused.
"They know they are not favourites, they had nothing to lose and the French are dangerous when they are in that position.
"I knew it was important to get three points here if we want to have a chance.
"I said yesterday [Tuesday[ we needed 10 points at least so to start with three is good.
"Marseille had a very good first half but we didn't make big mistakes at the back and were patient enough to win it in the second half.
"I felt we were a bit within ourselves in the first half, a bit timid, and Marseille were more mobile and first on the ball.
"They dropped in the second half and we took advantage of our strong moments. That got us three very important points."
Wednesday's result means Arsenal have now won 10 successive away games on the road, including beating Fenerbahce, Fulham and Sunderland this term.
Ramsey has scored in all of those matches and, after tonight's strike, has six for Arsenal already this season.
"Honestly, I didn't expect him to score so many goals," Wenger said.
"He's especially improved in his passing, his technical quality. He was always in good positions in the box, but scoring is a bit cyclic.
"You have periods when it goes in and others when it doesn't. For me the most important thing is the quality of his game."
But, given the severity of his injury, did Wenger ever fear Ramsey would fail to reach his potential?
"I decided to be patient with him because when you have been injured for such a long time it takes a while to get back to your best," he said.
"The only thing is, you never know if he will come completely back.
"But when you are injured before 20, you come back to your normal level and improve like you have not been injured."
It was not all good for Ramsey tonight, though, as he was adjudged to have tripped Andre Ayew in stoppage time.
A penalty was awarded from which younger brother Jordan Ayew struck home, making the scoreline a better reflection of what was a tough match for the Gunners.
"I knew Marseille would be difficult," Wenger said.
"I think the only the people that don't think Marseille can make it tough for us is people from Marseille.
" I don't think [Marseille's hopes are over]. If you remember two years ago the first game we came here and won.
"Marseille then went to Dortmund and won, qualifying from the group. I do think they have to take positives from aspects of today's game and continue."
For Marseille manager Elie Baup, though, that is easier said than done right now.
"I have this feeling of frustration, of deception, but unfortunately the result is here," he said.
"Points are worth a lot in every game and, as we have seen, Dortmund have lost in Naples.
"It is not going to be simple playing in Dortmund but there are six games in the group and we will have to continue to show the quality we showed today and try to be more efficient."