The Pharaohs have already secured top spot in Group H with Bob Bradley's side having won all of their five fixtures to date.
They face Guinea on Tuesday before the draw for round three takes place on September 16.
Egypt will go in to the hat along with the other nine group winners with just a two-legged play-off separating the north African nation from a first appearance at the World Cup since 1990.
And captain Wael Gomaa wants a tough challenge to be meted out - so there is no chance complacency will cost Egypt a place in Brazil next summer.
"I would prefer to face Ghana or Nigeria instead of Cape Verde," he said.
"It's because our players would be taking the game seriously against Nigeria or Ghana, but against Cape Verde, it won't be the same.
"Another reason is that we have already been successful against Nigeria and Ghana as we have experienced playing them before in the African Cup of Nations, unlike Cape Verde."
Group winners Algeria host Mali in the final Group I match but, although there is nothing to play for in terms of World Cup qualification, both sides want to secure the three points in Blida.
Mali sit second and coach Amadou Diallo has challenged his players to play for pride.
"Things could not be more clear - we are eliminated," he told malijet.com
"That is a difficult sentence to digest and we are all embarrassed by this elimination. We have a game to play, an honor to defend. We play to win.
"We give a lot of consideration to this game. We did not come all this way so far to come lose.
"We are not here to be scapegoats. As I said, we have our honour to defend."
Meanwhile, assistant coach Noureddine Korichi has challenged Algeria's players to prepare for the third round of qualifying with a winning end to their group campaign.
"We play every game to win," he is quoted as saying on aps.dz.
"This game precedes the play-offs and a win would provide an appreciable wealth of confidence."