The 20-year-old midfielder has been rewarded for his impressive performances for Sevilla and his role in France's maiden Under-20 World Cup win this summer with a place in the squad to face Belgium on Wednesday.
The former Lens man told L'Equipe: "I am a bit surprised by all this. It has happened very quickly. It is a big step from the age groups to the senior side.
"I am a bit nervous. I have no particular target, the first thing is to discover what life is like in the France squad.
"I have only recently returned to training but I'm ready for anything. I came down quickly after winning the world title. I had to because time passes quickly and there is already a new season to prepare for."
Lille midfielder Rio Mavuba is back in the squad for the first time since last September after a series of knee injuries.
Mavuba's absence has coincided with the emergence of Blaise Matuidi, Yohan Cabaye and Paul Pogba but with the trio all suspended for the next World Cup qualifier against Georgia, they have been left out of this squad.
That gives Mavuba and Kondogbia the chance to stake their claim, along with St Etienne's Josuha Guilavogui and Toulouse's Etienne Capoue.
"A few players have 'scored points'," Mavuba admitted as he reflected on his long absence. "I have to make up for lost time.
"My aim for now is just to stay in the squad. I hope the injuries that troubled me last year are behind me."
Also returning is Eric Abidal, a summer signing for Monaco after his release from Barcelona.
The defender will start against the Red Devils - his first international appearance since last February, having battled cancer and undergone a liver transplant.
Belgium captain Vincent Kompany is relishing the test against Les Bleus as his talented side aim to prove they belong at the same elite level as their more established opponents.
Kompany: "France are a talented team with very good players like Samir Nasri.
"They have more experience than us. They are regularly in the final stages of the Euros and the World Cup and there is no substitute for that.
"We are trying to get ourselves to a major tournament. Wednesday will be a prestigious game."
Kompany is one of four starters already confirmed by coach Marc Wilmots, alongside fellow defender Sebastien Pocognoli, Chelsea keeper Thibaut Courtois and midfielder Axel Witsel of Anzhi Makhachkala.
PSV Eindhoven teenager Zakaria Bakkali misses out after suffering a thigh strain in training and Tottenham midfielder Mousa Dembele is doubtful with an ankle injury, while Tottenham defender Jan Vertonghen is absent.