Heading into the encounter four points off the pace, Harimau Selatan struggled to find a way past the defending champions in the opening 45, but the deadlock was broken in the 65th minute when Malaysia international Norshahrul Idlan Talaha opened the scoring.
Three minutes later, fellow Kelantan old boy Nurul Azwan Roya added a second for the hosts to wrap up the three points, which were enough to take them above ATM into second place.
Fourth-placed Selangor kept alive their slim titles hopes after cruising to a 2-0 victory over Terengganu.
Liberia international Francis Forkey Doe fired them in front in the 23rd minute but the result was never guaranteed until a minute from time, when he grabbed his second of the game to kill off the Turtles' resistance.
In Wednesday's final game, Pahang beat Negri Sembilan 2-0 to bring their opponents back down to earth, after the league's bottom side had recorded their first win of the campaign with a 2-1 triumph over ATM last Saturday.
Razman Roslan put Tok Gajah ahead at the Tuanku Abdul Rahman Stadium six minutes before the break when he scored from the spot, before Damion Stewart made sure of the result in the 55th minute with a second.
Wednesday's Malaysia Super League Results
Negri Sembilan 0-2 Pahang
Selangor 2-0 Terengganu
Darul Takzim 2-0 Kelantan