Manchester City manager Roberto Mancini has indicated he will make wholesale changes against Aston Villa, though Carlos Tevez and Mario Balotelli are likely to lead the line.
Meanwhile, Villa defender Joe Bennett is grateful for an early opportunity to make amends for Saturday's 4-1 drubbing by Southampton.
"We have the cup game at Manchester City. It's good to get a game so quickly to put things right. We want to learn from what's happened and move on quickly," he said.
Chelsea and Wolves have also indicated they will make sweeping changes for their showdown at Stamford Bridge.
"The team I'm putting out can do exactly the same as the team I could have put out - they are hungry and waiting for their chance," Wolves boss Stale Solbakken said.
"They are also fresh - if you meet Chelsea with many players who have played three games in six days you will struggle to cope."
Manchester United host Newcastle in an all-Premier League tie, while npower League one outfit Coventry travel to Arsenal.
Leeds manager Neil Warnock insists his players will meet Everton at Elland Road unburdened by expectations.
"There's no pressure on us in this competition because everybody will expect Everton to win, so we can go out and enjoy it," Warnock said.
"Everton are very high on my list of potential favourites to win this competition.
"Teams like Everton and Newcastle have got a great chance of winning it this year, so they will have a very strong side out.
"But we can give most Premier League teams a run for their money."
Michael Laudrup wants his Swansea side to quickly return to winning ways when they travel to League One Crawley.
The Swans head to the Broadfield Stadium on the back of consecutive Premier League defeats to Aston Villa and Everton.
"We want to get that winning feeling back because you go from everything being perfect by winning two games and getting a draw where we played very well, and then suddenly you lose two games. You have to be careful this run does not extend," Laudrup said.
"We don't want to lose three games and then it's four games since we last won.
"Football turns quickly and that's why we need to get back on the winning track as soon as possible."
The continued presence of holders Liverpool in the Capital One Cup hinges on a tricky clash at West Brom, who occupy fourth place in the Premier League.
Jimmy Bullard is expected to be the only absentee for MK Dons when Sunderland visit stadium:mk.
Bullard has been nursing a knee injury and the experienced midfielder may need to see a specialist about the problem.
Dons assistant manager Mick Harford, born in Sunderland and a supporter of Sunderland, said: "They are my hometown team and I have supported them since I was a kid.
"I always will be a big fan so to get them at home is great for me, and we are all looking forward to testing ourselves."
Tuesday's Capital One Cup Fixtures
Wednesday's Capital One Cup Fixtures
Manchester United vs Newcastle
Carlisle vs Tottenham
Arsenal vs Coventry
West Brom vs Liverpool
QPR vs Reading
Norwich City vs Doncaster Rovers