All four encounters will see Premier League teams go head to head.
Everton vs Chelsea
Chelsea look set to turn to their youngsters and fringe players once again in Wednesday night's Carling Cup fourth-round tie at Everton.
The likes of Romelu Lukaku, Josh McEachran, Oriol Romeu, Ryan Bertrand, Salomon Kalou, Florent Malouda, Alex and Paulo Ferreira will all be expecting to feature at Goodison Park after starting in the previous round against Fulham.
Didier Drogba, Ashley Cole and Jose Bosingwa are all suspended and Raul Meireles is cup-tied, while everyone else who started Sunday's controversial Barclays Premier League defeat at QPR could be rested completely or on the bench.
Tim Cahill and Louis Saha could return to the Everton starting line-up with boss David Moyes set to make changes.
Cahill and Saha could be recalled having both come off the bench - with the latter scoring - in the 3-1 Premier League victory over Fulham on Sunday.
Moyes says he has "a few knocks" in the squad to assess, while James McFadden, who rejoined the Toffees last week, is still working his way back to full fitness after the serious knee injury he suffered last season.
Victor Anichebe remains sidelined with a groin problem.
Everton (from): Howard, Heitinga, Hibbert, Neville, Distin, Jagielka, Baines, Barkley, Fellaini, Osman, Rodwell, Drenthe, Cahill, Stracqualursi, Mucha, Bilyaletdinov, Vellios, Gueye, Saha, Coleman, Hahnemann.
Chelsea (from): Cech, Ivanovic, Alex, Ferreira, Terry, Luiz, McEachran, Mikel, Romeu, Lampard, Mata, Malouda, Torres, Anelka, Sturridge, Lukaku, Kalou, Turnbull.
Stoke vs Liverpool
Liverpool have Lucas Leiva available again for Wednesday night's Carling Cup fourth-round clash with Stoke after the midfielder completed his one-match suspension.
Reds boss Kenny Dalglish is expected to make a number of changes for the tie at the Britannia Stadium, although Craig Bellamy will be hoping to keep his place having scored in Saturday's 1-1 Barclays Premier League draw with Norwich.
Daniel Agger made his return from injury as a substitute in that game and could be among those coming into the team.
Defender Jonathan Woodgate could return for Stoke after three games out with a calf injury.
Winger Jermaine Pennant will be assessed ahead of the clash with his former club after missing the last two matches with a hamstring problem.
Danny Higginbotham, out since April with a knee injury, could be involved as he looks to step up his comeback after playing for the reserves.
Stoke (from): Begovic, Sorensen, Nash, Wilson, Huth, Shawcross, Upson, Wilkinson, Whelan, Whitehead, Diao, Etherington, Walters, Shotton, Arismendi, Pennant, Delap, Crouch, Palacios, Jerome, Jones, Higginbotham, Woodgate.
Liverpool (from): Reina, Kelly, Carragher, Skrtel, Agger, Enrique, Henderson, Gerrard, Adam, Downing, Lucas, Kuyt, Suarez, Doni, Johnson, Coates, Aurelio, Flanagan, Spearing, Rodriguez, Bellamy, Carroll, Robinson, Wilson.
Wolves vs Manchester City
Owen Hargreaves has been ruled out of Manchester City's Carling Cup fourth-round tie at Wolves on Wednesday night.
Hargreaves, who made a goalscoring debut for City in the last round, would have been in line to play as manager Roberto Mancini considers a number of changes, but has a slight calf niggle.
Mancini otherwise has a fully-fit squad but Carlos Tevez, the subject of disciplinary proceedings, is highly unlikely to be recalled.
Wolves boss Mick McCarthy confirmed that he will make changes to his side for the game.
Adlene Guedioura, Nenad Milijas, Sam Vokes, Dorus De Vries, Jody Craddock, Stephen Hunt, Matt Doherty, David Edwards and George Elokobi will come into contention to start.
But defender Ronald Zubar's hopes of a comeback have been dashed after he suffered a groin injury during training.
Wolves (from): Hennessey, De Vries, Stearman, Johnson, Berra, Ward, Craddock, Doherty, Elokobi, Hammill, Henry, O'Hara, Jarvis, Guedioura, Milijas, Hunt, Edwards, Ebanks-Blake, Doyle, Vokes.
Manchester City (from): Hart, Pantilimon, Taylor, Richards, Zabaleta, Lescott, K Toure, Kompany, Savic, Clichy, Kolarov, De Jong, Milner, Barry, Y Toure, Johnson, Nasri, Silva, Dzeko, Balotelli, Aguero, Razak, Suarez, Bridge, Rekik, Scapuzzi, Onuoha.
Blackburn vs Newcastle
Newcastle will be without midfielder Cheik Tiote and striker Shola Ameobi for Wednesday night's Carling Cup fourth-round tie against Blackburn.
With Ameobi already sidelined for at least a month after pulling a hamstring in Saturday's win over Wigan, Tiote has also been ruled out by a knee injury suffered in the same game.
The Ivory Coast international is rated as doubtful for the Barclays Premier League game at Stoke which follows on Monday.
Defender Steven Taylor is doubtful for this game after breaking his nose in a punishing encounter against the Latics.
Blackburn boss Steve Kean is planning to play a reasonably strong side.
Under-fire Kean, whose team sit bottom of the Barclays Premier League table, is desperate for a win and he is unlikely to make wholesale changes from the side beaten 2-1 by Tottenham on Sunday.
He will have to make at least one alteration with Steven Nzonzi suspended after picking up a fifth yellow card of the season while Vince Grella (hip), Ryan Nelsen (knee), Michel Salgado (hamstring), David Dunn and Scott Dann (both calf) are injured and Jordan Slew cup-tied.
Blackburn (from): Robinson, Lowe, Samba, Givet, Dann, Olsson, Givet, Petrovic, Hoilett, Roberts, Bunn, Hanley, Formica, Pedersen, Vukcevic, Rochina, Yakubu, Goodwillie, Anderson, Ribeiro, Aley, Cotton, Blackman.
Newcastle (from): Krul, Elliot, Simpson, R Taylor, Santon, Ferguson, Coloccini, S Taylor, Perch, Cabaye, Gutierrez, Marveaux, Obertan, Gosling, Guthrie, Ben Arfa, Abeid, Vuckic, Smith, Ba, Best, Lovenkrands, Sammy Ameobi.