Holloway made eight changes to his side from Saturday's impressive 3-1 win at Cardiff in the npower Championship, but the standard of play was equally eye-catching as the Seasiders eased to victory in the fourth-round replay at Hillsborough.
Blackpool's win set up a fifth-round tie against Everton at Goodison Park and came courtesy of three goals from the top drawer by Matt Phillips, Lomana LuaLua and Ludovic Sylvestre.
Holloway admits the showing of his players has caused some confusion in his mind.
"I thought we were as professional as we have been since I've been here," he said.
"The goals we scored, the way we defended and then attacked, we didn't get them much of an opportunity.
"I was delighted for myself and the team I picked and some of those performances are going to cause me some problems in the future.
"I don't think anyone could tell me my best team now and I don't think I know either and that's what makes me proud.
"I thought we looked like a foreign team rather than an English team with the way we passed it."
Wednesday boss Gary Megson said he wanted to progress but was happy to now concentrate on their bid to earn promotion from League One.
"We certainly wanted to win but everything at this football club points to being successful in the league," he said.
Millwall manager Kenny Jackett praised his side's battling qualities after they defeated Southampton 3-2 in Tuesday night's other fourth-round replay at St Mary's.
The Lions were 2-1 down with 11 minutes remaining but Dany N'Guessan levelled before Liam Feeney struck a superb stoppage-time winner.
Millwall, who are struggling in the Championship, now face a home tie with Bolton and Jackett believes his side can take confidence from the win.
"It was an excellent game," he said. "We played our part. We caused them lots of problems.
"I think both sides went for it and from a neutral's point of view I am sure it was an excellent game."
Millwall broke the deadlock after 17 minutes when Liam Trotter struck home. Adam Lallana pegged the visitors back with a solo goal and after the break substitute Rickie Lambert fired Southampton into the lead.
However, N'Guessan and Feeney goals extinguished Saints' hopes of progression - much to manager Nigel Adkins' disappointment.
"It is not a good night for us," he told BBC Radio Solent. "Obviously we wanted to win the tie and we felt we had enough on the pitch to go and do that."