Lampard was withdrawn in the first half of City’s midweek friendly against Hamburg in Abu Dhabi as a precaution after suffering an injury in the warm-up.
Playmaker Samir Nasri (calf) is likely to be out for at least another fortnight while central midfielder Yaya Toure is at the African Nations Cup.
Defender Tomas Kalas is Middlesbrough manager Aitor Karanka’s only fresh doubt ahead of the game.
The 21-year-old Czech Republic international, who is on loan from Chelsea, took a kick to the ankle during Tuesday night’s league victory over Cardiff and is being assessed.
Former England defender Jonathan Woodgate was an unused substitute against the Bluebirds and is in contention for just his second senior appearance of the season at the Etihad.