The Germans are in Norway looking for their first win in Group K after drawing their opening game against Metalist Kharkiv.
The Trondheim club won their first match against Rapid Vienna and Voller wants to make sure they do not pull further clear.
"Clearly, we are going to try and win in Trondheim," Voller told his club's official website. "We want to secure qualification from the group as quickly as possible. But the task will not be easy."
Bayer have had an up-and-down start to the Bundesliga season, with three wins and two defeats from their opening six games to lie seventh in the table.
Rosenborg are third in their domestic league, two points off top spot.
Jan Jonsson's side won 2-1 in Vienna in their opener and the coach feels the encounter represents another opportunity to pick up points.
"It is of course difficult to win, but we must be aware that the chance is there," he said on Rosenborg's website.
"We are boosted by the events in Vienna and the way we've played at home in the past. We should be well organised and defend well, but have faith in what we can do when we get the chance."
Striker Rade Prica is as familiar as any of the home team with their opponents, having spent four years in German football with Hansa Rostock.
"We know that we have nothing to lose in this match," he added.
"Leverkusen are expected to win and as such we have no pressure on us. We got a very good start in Vienna with three points, so I'm really looking forward to the match."