His side are hoping to end a 16-year wait for a home win in European competition.
Gladbach's preparation for the visit of the Turkish side has been far from perfect as they were on the end of a comprehensive 5-0 drubbing by reigning Bundesliga champions Borussia Dortmund at the weekend.
However, Gladbach, who have lost their last two European home games - although they are separated by nearly 16 years - will be looking to reverse that fortune in the Group C fixture.
Favre was focussing on the few positives from the defeat by Dortmund and is looking to build on the point earned from the 2-2 draw against AEL Limassol on matchday one.
"It wasn't all bad there," Favre said of the loss at the Westfalenstadion. "The first 35 minutes were good, for example, and it was also OK from the 46th to the 70th minute.
"The Dortmund game is a thing of the past, though, and there's no point in discussing it.
"We have to look forward now and concentrate on the match against Fenerbahce."
Gladbach goalkeeper Marc-André ter Stegen could be fit for the match after he resumed training following a bruised hip and pelvis but the game could be too soon for midfielder Luuk de Jong who has a lacerated foot.
Fenerbahce, who are currently seventh in the Turkish Super Lig after only winning twice in their opening six games, also drew the first match of their Europa League campaign, 2-2 against Marseille.