Two years ago Villas-Boas won the competition in Dublin to cap off a remarkable year that saw him collect four trophies and be headhunted for the Chelsea manager's job.
Things quickly went sour for the 34-year-old at Stamford Bridge, where he was sacked after nine months in charge.
Now, fresh from Sunday's morale-boosting win over Reading - his first in charge of Spurs - the Portuguese hopes to end his two-year drought by leading the Londoners to victory in the Europa League.
"It does seem a long time since I won it with Porto," Villas-Boas said. "A lot of things have happened since then. The memories are still present but at this time I can't live off the past.
"In our position we can't think too much about the past. In this life you constantly have to motivate yourself and put pressure on yourself to win more (trophies).
"This time it would be wonderful to win it again for Tottenham."
Lazio manager Vladimir Petkovic is sad to hear Paul Gascoigne cannot attend Thursday's game and hopes the troubled star will be able to make the reverse fixture between his two former employers in November.
Gascoigne joined Lazio from Tottenham 20 years ago and became a cult hero in three years at the Stadio Olimpico before returning to Britain.
He declined an offer to attend Thursday's game between his two most famous employers due to "personal reasons", but Petkovic hopes he will be in the stands at the Stadio Olimpico when the two sides meet on November 22.
"I followed Gascoigne when he was at Lazio and I know he was an idol to the fans so I am very sorry that he won't be there tomorrow [Thursday] and that he is having these problems at the moment," Petkovic said.
"I certainly hope that with the inner strength that he undoubtedly has, he will be able to recover and that he will be in Rome for the second leg."