Les Girondins, who finished fifth in Ligue 1 last season, won a dramatic play-off against Red Star Belgrade to earn their place in Group D and will open their campaign against Club Brugge on Thursday.
And Nguemo told the club's website: "The Europa League is a notch above the league. In the league, if you slip up, you can recover and that is the difference.
"For the club, the league is most important. For a player, the approach to matches is different. You get to participate in a mini-tournament with the best teams.
"It is the reward for a good previous season. You must savour it."
Forward Henri Saivet added: "The Europa League is a competition which is growing and we will play whole-heartedly in it. We gave everything last year and in this year's play-offs to play in it.
"It is important to compete well in this competition. On Thursday we will play at home against a Brugge team who are playing well and it will be a good match."
Fahid Ben Khalfallah misses out through injury while Nicolas Maurice-Belay is suspended after his dismissal in the 3-2 second-leg win over Red Star, when Nikola Mikic's last-minute goal looked to have seen the Serbian side through only for Yoan Gouffran to grab a stoppage-time winner.
The Belgian side are dealing with a host of absentees of their own, with Thomas Meunier, Lior Rafaelov, Ryan Donk, Jim Larsen, Niki Zimling and Ivan Trickovski all sidelined.
Jonathan Blondel, himself only just back to full fitness, told the club website: "The injuries do not make it any easier, but our core is strong. We have enough quality to deal with the injuries.
"At the start of the season we wanted, as a group, to reach the Champions League. Unfortunately, that just did not work out.
"The draw in the Europa League has also not proved easy for us, but okay. We want to pick up something in Bordeaux.
"In our group Newcastle and Bordeaux are the favourites, because both teams play in a stronger league than ours, but we will give everything to qualify."