After successfully negotiating the group stages Stoke move into the knock-out round with a two-legged tie against third-place La Liga side Valencia.
Stoke lost out to Besiktas 3-1 in the final round of group-stage matches resulting in them ending in second, one point behind the table toppers.
Despite narrowly missing the opportunity to top the group frontman Fuller is relishing an encounter with a top European side while remaining confident his side can defy the cynics.
"People will say that we have no chance, but they also said that in the group stage," he told the Daily Star. We won't go out there just to make up the numbers, we will be looking to cause a shock by going through to the last sixteen.
"It's a draw that all of the players wanted. We were speaking about it before the draw took place and praying for Valencia.
"They were probably the best side we could have drawn, but as players you want to put yourself up against the best teams in the world, Valencia are certainly one of those."
Potters boss Tony Pulis has been conducting thorough research ahead of the showdown by making the trip to Spain to watch their opponents register an emphatic 4-0 victory over Sporting Gijon to retain third spot in the top flight.
And despite going into the match on the back of four straight defeats Pulis expects Stoke to draw on their European form with three wins and two draws in the group stages.
"We've had some great results in Europe this season, particularly at our place, but this opposition is a step up from what we've faced so far," he added.
"They are a Champions League team, really, and the third-best team in Spain, but are not too far behind Barcelona and Real Madrid."