United take on Ajax for only the second time ever on Thursday, and already their away form in Europe has been a major area of concern for manager Sir Alex Ferguson.
The Red Devils' only win on the road in their ill-fated Champions League campaign was an uninspiring 2-0 win over Otelul Galati, with their other games against Benfica and Basel resulting in a draw and a loss respectively.
Despite many believing playing at home in the second leg is always an advantage, Hernandez insists United will not be taking things for granted, and will be looking to win Thursday's round-of-32 first leg at the Amsterdam ArenA.
"Playing at home in the second league is important but it's only a small advantage - it doesn't guarantee victory," Hernandez said on the club's official website.
"It'll be a difficult game but we'll go to Amsterdam looking to win.
"The Champions League is the best competition in Europe and it's a bit strange to be in the Europa League. But we want to win every tournament we enter.
"Both teams have a lot of history in Europe, so it should be a great game."
With United also eliminated from the FA Cup, they will not have a fixture this weekend, meaning their next game after Thursday's match will be the return leg at Old Trafford next Thursday.