Last year`s meeting between the two at White Hart Lane ended in a 3-3 draw, and talk has been building about the latest chapter of the rivalry.
Before that, though, Spurs have to deal with Shamrock. The Dublin-based team became the first Irish club to qualify for the main stages of a European competition earlier this summer when they upset the odds to beat Partizan Belgrade.
Rovers, who count former Spurs player Rohan Ricketts among their ranks, were given a swift reminder of the tough nature of European competition two weeks ago when they lost 3-0 at home to Rubin Kazan.
Redknapp, whose team opened their Europa League campaign with a 0-0 draw at PAOK Salonika, intends to rest the majority of his first team on Thursday, but insists Spurs will not be taking the match lightly.
He said: "I have got two eyes on the derby. I'm not putting my first team out tomorrow [Thursday] but it'll be a team with some good, experienced players that will contain probably seven or eight full internationals.
"Players like Gareth Bale and Adebayor will not play. I can't afford to miss them for the weekend.
"It's a game we're entitled to win. But they will rise to the big occasion. They're a good side and have done well.
"[Assistant manager] Joe Jordan went to watch them and was impressed. They went to Belgrade and won.''
Shamrock manager Michael O'Neill is expecting a difficult challenge against Tottenham tomorrow night [Thursday] - regardless of what team the London club name.
Despite the likelihood of Shamrock facing some of Tottenham's squad players, O'Neill believes they will still be underdogs come kick-off.
He said: "We saw in the opening Europa League game some of their younger players being blooded and they gave an excellent account of themselves.
"Whilst we are unsure of what we will face personnel-wise, there will probably be a sprinkling of experienced players mixed with some of the younger players they have here.
"Tottenham are building a Champions League squad here, that is what it is. When you have that level of ambition and that level of commitment you have to have a player of that calibre."