The Belgian side drew 0-0 at Hannover in their first group game and in eight matches in the Jupiler League, Jose Riga's side have managed just 10 goals to lie seventh, six points behind leaders Club Brugge.
Standard have found the net just once in their last three games and played out a goalless draw with Cercle Brugge last time out on Sunday.
Midfielder William Vainqueur is at a loss as to why Les Rouches are encountering such a problem given they address the situation in training.
In quotes reported in lalibre.be, the Frenchman said: "We already do in the week - this is perhaps not enough.
"But it is by working harder and harder that the wheel will turn in our favour."
It is the team's first meeting in competition and while Standard struggle to make and convert chances, the Danish side have enjoyed a flying start to their SAS-Ligaen campaign where they stand 10 points clear with nine wins and a draw in their 10 games so far.
Roland Nilsson's team edged a 1-0 win over Vorskla on matchday one thanks to Morten Nordstrand's second-half penalty.
However, while form may be on the Danes' side, recent history backs the Belgians who have lost just once in their last seven European home games - against Hamburg in the Europa League last eight in 2010.
Copenhagen have won only one of their last five European away games, beating Shamrock Rovers 2-0 in this season's Champions League third qualifying round.
Miklos Molnar is the only Dane to have ever played for Standard and he believes Copenhagen will face a tough test.
He told fck.dk: "There is no doubt that Standard Liege is a large and very traditional club in Belgium. There's probably only Anderlecht and Club Bruges who are greater.
"Although I do not follow the club so much now, I'm sure FC Copenhagen will have to go into the match with great respect, for I can't imagine that it will be a walkover for FCK."