Mainz and Anderlecht both remain unbeaten in the Europa League group stages after they played out to a 1-1 draw at the Opel Arena.
Roma and Villarreal had to settle for disappointing draws while there were key wins for Inter Milan, Fiorentina and Manchester United in Thursday's Europa League action.
Manchester United moved to the top of Group A in the Europa League after they cruised to a 4-1 win over Fenerbahce at Old Trafford on Thursday.
Southampton were left to rue their missed chances as 10-man Internazionale secured a narrow 1-0 win in the Europa League at the San Siro on Thursday.
FC Schalke 04 continued their strong Europa League form as they saw off Krasnodar 1-0 in a Group I encounter at the Kuban Stadium.
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