Italy go into the Euros on a low after losing 3-0 to Russia in their final friendly match last week while their squad is rocked by the Scommessopoli scandal, with first choice full back Domenico Criscito already withdraw from the team.
However, Marchisio doesn't feel that the bad news will affect the Azzurri when Euro 2012 kicks off with their match against Spain, reminding everyone of their 2-1 win over the reigning world champions last August.
"We are not afraid of anyone. We are Italy, a great country," the Juventus man said at a press conference, "We will face the champions of Europe, who play the most beautiful football in the world.
"But last summer we beat them after playing a great game and we need to play like we did then."
The Juventus midfielder also feels that a repeat of their debacle in the 2010 World Cup is unlikely.
"We should not worry about that, but work calmly, without fear, or else it would be better not to go," he added, "We should not leave for the Euros fearing a repeat of what happened in the 2010 World Cup."
However, Marchisio agreed that Italy could make do without the betting scandal pulling them into the negative spotlight.
"It's annoying (the match-fixing scandal) especially for us because the rest of the football world is not like that. We are obviously waiting for the sentences that will be given out. It is right that those who have made mistakes should pay. The only thing we have to do is to wait and hope that there will be exemplary punishments."
Italy face Spain in their opening match on 10 June.