Muller and Ozil are two of Germany's key players at the moment, and have been ever-present in Joachim Low's squad since starring at last summer's World Cup in South Africa.
And Muller, whose adaptability has seen him deployed all over the park for Bayern and Germany, insists he does his best work in a central role, although he admits having a fluid structure with versatile players like Ozil helps himself and the team.
"I see myself most effective behind a tip [main striker]," Muller said on DFB's official website. "I've always said so and it still applies.
"Mesut often comes with his left foot over to the right and then I'll move inside.
"For my game, I just need one or two combination players around me."
Ozil and Muller combined for eight goals in Germany's recent Euro 2012 qualifying campaign, where Low's men finished top of Group A by winning all ten of their matches.