Spain have already guaranteed their place in next summer's European Championship in Poland and Ukraine after winning all of their Group I qualifiers so far.
However, Scotland face an altogether different proposition, leading third-placed Czech Republic by just a point going into Tuesday's final round of qualifiers.
And with a strong tartan presence at Liverpool in the form of Adam, as well as manager Kenny Dalglish, coach Steve Clarke and young defender Danny Wilson, Reina admits he would love to see Scotland qualify for Euro 2012 as well, although he insists Spain will be looking to maintain their 100% record.
"I spoke to Kenny and Charlie just before I left but we just congratulated each other on the victory over Everton," Reina told Liverpool's official website.
"We didn't speak too much about the international game. I'm sure they will want me to tell the [Spain] players to go easy on Scotland but they know that won't happen.
"The target is not to lose a single point in the group so even a draw wouldn't be good for us.
"We have to be professional. Once Spain's job is done then I would want Scotland to get second place but that would mean the Czechs have to lose to Lithuania. And that's possible.
"My preference would be for the Scots to go through because of Charlie, the manager, Steve Clarke and young Danny Wilson."
And Reina is under no illusions that Adam will pose a huge threat to Spain in Alicante on Tuesday.
"Charlie will be crucial to Scotland in Alicante - he is one of the best players in their team.
"If they want to do something big then he holds the key."
Having been aware of the danger Adam possesses after playing against him last season while the Scot was at Blackpool, Reina admits he is pleased with the impact his new team-mate has made since his £7million move in the summer.
"It's a case of so far, so good for Charlie at Liverpool. The team is improving all the time and Charlie is also getting better.
"I probably analysed him more than most before he signed because I knew how dangerous he is at free-kicks.
"He also has great deliveries. Charlie is a great player to have in the squad and he can become very important for us.
"Playing for Liverpool isn't easy but Charlie is prepared for it. He has been at Rangers and has Champions League experience."
Adam has made a bright start to his Liverpool career so far, filling in capably for injured captain Steven Gerrard, and laying on number of assists for his team-mates with his dangerous deliveries.