Arsenal must recover from a 3-1 home loss to Bayern Munich tomorrow in order to progress. It is 17 years since the last time the Champions League quarter-finals were played without a British representative, and only the second time it has happened since the introduction of a group stage preceding the quarter-finals in 1994-95.
Here Press Association Sport looks at those past seasons of failure.
A disastrous campaign which saw Premier League champions Blackburn and Scottish title-holders Rangers finish bottom of their respective groups. Rovers recorded their one and only victory against Norwegian side Rosenborg at home. Juventus were the eventual winners that season, beating Ajax on penalties after a 1-1 stalemate.
Manchester United led a better showing from an English perspective in the 1996-97 season as they set up a semi-final showdown with Borussia Dortmund. However, two 1-0 defeats prevented Sir Alex Ferguson's men from reaching the final as the German side went on to claim a first and so far only Champions League title.
Manchester United made it to the group stages but finished third in their group having been pipped by Spanish giants Barcelona on goal difference, therefore failing to make the quarter-final cut. The tournament was won by an Ajax side featuring the experience of Frank Rijkaard and the youthful promise of Patrick Kluivert and Clarence Seedorf. Louis van Gaal's side beat AC Milan in the final.