Lille will begin their Champions League challenge against Danish champions FC Copenhagen as the French club look to claim a place in the group stage.
Les Dogues finished an impressive third in Ligue 1 last season and victory over FCK in their two-legged play-off would see them join French champions Montpellier and runners-up Paris St Germain in the next round.
Spanish side Malaga will be hoping to put their financial concerns aside when they meet another money-troubled side, Panathinaikos.
The La Liga club have previously said they are willing to listen to offers for any player because of severe economic troubles, and have already sold midfielder Santi Cazorla to Arsenal.
In other play-off ties, Spartak Moscow face Fenerbahce and Udinese take on Braga.
Basel meet Romanian side CFR Cluj, Scottish champions Celtic take on Helsingborg and BATE Borisov face Hapoel Kiryat Shmona from Israel.
Cypriot club AEL Limassol will go up against Anderlecht and Dinamo Zagreb take on Maribor of Slovenia to complete the fixtures.
The first legs will be played on August 21 and 22, with the return matches taking place the following week.