AC Milan currently lead Juventus at the top of Serie A, with Massimiliano Allegri's men looking to make up for last season's defeat at the same stage of the competition to Tottenham by dumping the Gunners out of Europe.
Arsenal go into Wednesday's first leg of their last 16 tie on the back of successive Barclays Premier League wins which have propelled them back up into the top four.
Manager Arsene Wenger, whose side recorded a famous 2-0 win on their last visit to Stadio Giuseppe Meazza against the then holders four seasons ago, maintains the Gunners mean business.
AC Milan: Abbiati; Abate, Thiago Silva, Mexes, Antonini; Van Bommel, Nocerino, Seedorf; Boateng; Ibrahimovic, Robinho
Arsenal: Szczesny; Sagna, Koscielny, Vermaelen, Gibbs; Song, Arteta; Walcott, Ramsey, Rosicky; Van Persie.
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Wenger has warned that AC Milan striker Zlatan Ibrahimovic is a man for the big occasion ahead of Wednesday's UEFA Champions League clash.
"He is a great player," Wenger told the club's website, "If you look at his record, at what he has won, he has his own personality based on a strong belief in himself.
"That is a quality at the top level that can sometimes be seen as over-confidence but I don't think he is because he turns up with performances in the big games.
"That's why I believe he was at the Arsenal training ground before his career. Before he moved to Ajax we were interested in him, and he made a great career."
In the early kickoff, Zenit St Petersburg will be hoping to capitalise on their home advantage as they host Portuguese side Benfica in the freezing Russian winter, but Alexander Kerzhakov remains confident that the Russian Premier League champions can get a result, with their only advantage in the testing conditions a packed stadium of home support.
"We've probably had to play in weather like this more often than our opponent has but I don't think that that's an advantage for us," he said, "But I think our fans will come and fill the stadium, and that's probably the factor that will help us win the match in the end."
Wednesday's Champions League Fixtures
Zenit St Petersburg vs Benfica
AC Milan vs Arsenal