The Argentine had refused to come on as a second-half substitute, and in response to the Argentine's behavior, Mancini has arranged emergency talks with City's owners from the Abu Dhabi United Group on Thursday, according to reports in the Guardian.
The Italian is planning to seek permission from the club's hierarchy to freeze out the striker, despite the huge financial outlay that Sheikh Mansour has splashed on the star.
When asked if he will ever pick Tevez again, Mancini huffed: "No. If we want to improve like a team, like a squad, Carlos cannot play with us. With me, no - it is finished.
"It may not be my decision but if I'm deciding then, yes, he goes. For me, if a player earns a lot of money playing for Manchester City in the Champions League and he behaves like this - he cannot play again. Never.
"He has wanted to leave for the last two years. For two years I have helped him, and now he has refused to play. Never again", the Italian resolved.
Tevez's tantrum evoked much anger from Citizen fans both at home in Manchester, and the club were worried enough about a backlash that they asked for extra security to be ready for the team's return to Manchester airport upon their return.
Tevez himself had little to say about the matter, saying after emerging from the City dressing room: "I didn't feel right to play, so I didn't."
When told that Mancini is planning to freeze him out from the club, the Argentine replied bluntly: "I was top goalscorer here last season, I always act professionally so it is up to him."
Mancini, on the other hand, was not to be placated.
"This can never happen at a top club that one player can refuse to help his team-mates in an important match like tonight", the Italian raged.
"In the next day I'm sure I will speak with Khaldoon [al-Mubarak] because he is the chairman and he will decide everything but let me ask a question: Do you think at Bayern Munich a player would ever behave like this. At Milan? At Manchester United? No. That is the answer. It is the same for everyone."
The whole affair started after Mancini had taken off Edin Dzeko with Nigel de Jong, which triggered an angry outburst from Dzeko. The Italian was just as upset at the Bosnian's antics, and plans to drop the striker from their upcoming Premier League fixture against Blackburn Rovers.
Mancini defended his substitutions, saying:"I make the decision [about substitutions], not Carlos,"
"I think he was disappointed because he didn't go out for the first change - maybe. But when I said 'Carlos, go, for 35 minutes to the end,' he refused. I think that in 35 minutes we can change every result.
"For me, it's a bad situation because it's impossible if a player decides he will not help the team. It's impossible. We have 11 players and I can't accept that one player refused to go on to the pitch. I can't accept this."
Mancini also reserved some ire for Dzeko, saying: "He played a bad game, a poor game."
"Next time, maybe if he plays better he can stay on the pitch. He needs to improve his behaviour. I should be unhappy with his performance - not Edin."
The manager added: "This is the last time that one of our players leaves the pitch and moves his head like this [shaking head]. I can understand why a player is disappointed but I am furious with Dzeko and he will sit the next game next to me.
"This is the last time he has this behaviour. He is disappointed. But the manager can do what he thinks. We play every three days and one player can't play in every game."
In the aftermath of the drama at the Allianz Arena, the Italian also had to apologise to Tevez's compatriot, Pablo Zabaleta, after mistakenly believing that he had spoken out in favor of the striker.
"With Pablo, I made a mistake," he rued. "I have spoken with Pablo now and it's nothing."
The Citizen's 2-0 loss meant that the rest of the team were not spared a rebuke from Mancini, who raged: " "We played well for only 30 minutes and we conceded stupid goals.
We have another four games and in my opinion we can still go into the second stage. If we win the next three games we will go through. But a situation like tonight? Never", he concluded.