City have enjoyed a stunning start to the new season, with record signing Sergio Aguero and January arrival Edin Dzeko both scoring six goals in the Premier League.
Such are the riches at Mancini's disposal that Dzeko was left on the bench for Saturday's 3-0 win over Wigan Athletic as former captain Carlos Tevez made his first start of the season.
Balotelli, meanwhile, made just his first appearance of the campaign as a substitute against the Latics and will again miss out on selection when City face Napoli in the UEFA Champions League on Wednesday night.
The Italian is suspended for the start of the group phase after being sent off in the Europa League last season and Mancini is happy with his options up front.
Mancini said: "I count myself very lucky to rely on four strikers, especially in a situation where the team needs to play every three days. I can have a good turnover of the strikers.
"For now Mario will have to adapt to the situation, he will not be playing for the next few matches.
"Dzeko and Aguero are great players and Tevez has nothing to be afraid of.
"He is a player who always gives 100% performance and doesn't need to prove himself. He has already done so."
Meanwhile, Argentine ace Aguero believes his manager is the perfect man to learn from as he looks to continue the impressive start to his City career.
Aguero told UEFA's 'Champions' magazine: "Obviously the style of play here is different to Spanish football but I will adapt as quickly as possible and try to be fully focused during training sessions.
"I can learn from Roberto Mancini's experience as a striker. He will be able to help me. I hope I can fulfil what he has taught me and show that on the pitch."