The Argentina forward has delivered an instant return on Mancini's club record £38million outlay, scoring six times in just four appearances since his summer arrival from Atletico Madrid.
But the 23-year-old feels he still has much to learn and Mancini, a striker capped 36 times by Italy during a playing career which took in Sampdoria and Lazio, could be the perfect guide.
Aguero told UEFA's 'Champions' magazine: "Obviously the style of play here is different to Spanish football but I will adapt as quickly as possible and try to be fully focused during training sessions.
"I can learn from Roberto Mancini's experience as a striker. He will be able to help me. I hope I can fulfil what he has taught me and show that on the pitch."
Aguero is likely to get his next opportunity to impress as City make their eagerly-anticipated Champions League bow at home to Serie A side Napoli.
Edin Dzeko, another player in outstanding form with seven goals to his name already this season, is expected to return alongside him up front after missing Saturday's Barclays Premier League win over Wigan.
That would mean last season's top scorer Carlos Tevez missing out but Mancini is pleased to have such selection dilemmas.
One forward who cannot feature, however, is Mario Balotelli, who is suspended after being sent off against Dynamo Kiev in the Europa League last season.
Mancini said: "I count myself very lucky to rely on four strikers, especially in a situation where the team needs to play every three days. I can have a good turnover of the strikers.
"For now Mario will have to adapt to the situation, he will not be playing for the next few matches.
"Dzeko and Aguero are great players and Tevez has nothing to be afraid of.
"He is a player who always gives 100% performance and doesn't need to prove himself. He has already done so."
Midfielders Gareth Barry and James Milner are both doubtful and were due to be assessed on Wednesday morning.
The pair both trained on Tuesday but Barry continues to be affected by the ankle injury picked up on international duty last week while Milner suffered a clash of heads in the Wigan game.