Basel ended Manchester United's Champions League campaign prematurely in 2011/12, the season Chelsea went on to win the European Cup, with a 2-1 victory in the final group contest at St Jakob Park.
The Swiss side beat the Blues at Stamford Bridge in September, but since then Jose Mourinho's men have recovered to assume pole position in the standings courtesy of three straight wins.
It is unlikely Mourinho's men will miss out on the knockout stages - Chelsea need just a point from their remaining two fixtures, the second at home to Steaua Bucharest on December 11 - but Basle are determined to join them in the next round.
To do so, Basle, currently a point behind Schalke, must beat the Germans in the final group match next month, while also matching Schalke's result with Steaua against Chelsea. The third-placed team will drop into the Europa League.
Forward Fabian Frei said: "It's clear our first target is third place at the end of this group stage, but we will try to reach second place as well.
"Tomorrow [Tuesday] will be a very decisive game for us, but our first target is to get this one point, then we're sure of third position.
"Then we have this final game against Schalke, which would be great for us.
"I remember two years ago against Manchester United here and we had this final game and we won."
The defeat of United, finalists the previous season, was a memorable moment in Basle's history.
So too was the win in London on September 18, when Basle inflicted Chelsea's first home loss in the group phase of the tournament in nearly 10 years, ending a 29-match unbeaten streak.
"Chelsea took the lessons after we defeated them at home," Frei added.
"They underestimated us in the first game, maybe. Tomorrow it will be completely different. They will want to show how big the club is.
"We know what we can do and we're ready for the game. We've proven in the past we can handle big teams and the team is ready."
Chelsea beat Basle in the Europa League semi-finals after last season dropping into the second-tier competition before going on to win the tournament.
Now Basle are looking to dent the Londoners' Champions League revival, at least temporarily.
"We are looking forward to this encounter," head coach Murat Yakin said.
"We would like to stay in the Champions League over the winter.
"We'll see how the match develops tomorrow. We want to achieve our first home win here.
"It was nice after the win that we achieved in London. (But) I don't like to look back. We're focused now on the match tomorrow.
"A draw would be enough for Chelsea, but they want to go top of the group. They will try to win here tomorrow.
"We want to invest everything that we have to get the chance in our final match against Schalke for a decider if we can qualify for the next round or not.
"We have to be clever and smart and we want to show our spectators a great performance and fight for the win."