For the past two seasons the competition has proved disappointing and frustrating for the club with exits at the group stage on both occasions.
This year it has been different with progress to the last 16 for the first time - a landmark achievement in the club's development - secured in some comfort with two games to spare.
Back-to-back victories over CSKA Moscow in the last two Group D games have completed the task, glossing over their comprehensive loss to Bayern Munich earlier in the competition.
Until the knockout stages begin in February, City can now focus mainly on domestic matters.
Top spot in the group is still a possibility but with reigning champions Bayern having so far looked irrepressible, there is little doubt the club would be highly satisfied with the runners-up spot.
That gives Wednesday's visit from winless Czech minnows Viktoria Plzen, who were brushed aside 3-0 by City in September, the feeling of a dead rubber.
Manager Manuel Pellegrini, who guided former clubs Villarreal and Malaga to the latter stages, may be glad of that with a hectic schedule to come.
The Chilean said: "We have a lot of games in December, nine games in the Premier League in 35 days when we have played 11 games in two and a half months.
"These 27 points are very important for us to be near the top of the table.
"We have also to continue in Capital One Cup, we have to play against Leicester, so the target is to be near the top of the table and continue in cup.
"In the Champions League we achieved our target already but we will see what happens with Bayern in Moscow and we must win here against Plzen."
Despite the second round being new territory for City, with their strong squad and Pellegrini's track record, there is hope they can go further even further in the competition.
Striker Sergio Aguero said: "We've qualified from the group stages and hopefully we can go further.
"I think we have an excellent squad to progress in the Champions League but we know it will be difficult.
"We will wait and see what team we play in the next round and do our best to progress."