The lowdown: Defending Serie A Champions Juventus play host to the La Liga runners-up Real Madrid - both teams currently third in their leagues.
Juve have lost only twice this season, once to a Ronaldo inspired Real in an unlucky loss after Giorgio Chiellini's 48th minute red card, and another after losing a two goal lead against Fiorentina.
Real's defence have also been in a siesta for the last two games, letting in two goals less than eight minutes after gaining a three goal lead. The difference with Juve is roughly £85m - Gareth Bale's return to match fitness marks a milestone having created 10 out of 34 league goals for his team as well as his first brace for his new club coming against Sevilla - one of them from a free kick, a responsibility normally given to Cristiano Ronaldo.
The attention and responsibility that Bale now carries has allowed Real top scorer Ronaldo to focus on his finishing and five goals in the last two games is a clear statement of intent - especially with the record for goals scored in UEFA Champions League group stage standing at eight, just one more than the striker's tally thus far.
The replacements: The Italians will not have Chiellini to marshall the backline along with Mirko Vucinic, Simone Pepe and Stephan Lichtsteiner who are also sidelined but Fernando Llorente is expected to partner Tevez up front. The Spanish side will welcome back Raphael Varane at the heart of defence with left-back Fabio Coentrao and midfielder Xabi Alonso doubtful. Iker Casillas might also replace Diego López in goal.
The edge: Real only need a draw to ensure qualification with Galatasaray five points behind but Juve who are sitting in third with only two points, must win to keep their Champion's League hopes alive and you can be sure that Conte's men will be giving their all.
The Juventus Stadium, more intimidating than the previous Stadio delle Alpi which sold out only once before in the 2003 Champions League semi-final against Real Madrid, will play an important role as historically the team with the home advantage has always won encounters between the two giants. Midfield maestro Andrea Pirlo was also specifically rested by Antonio Conte with this match in mind.
What the FOX says?
The crucial factor will be the player dubbed by Italian media as the scourge of Italian football and Inter Milan's bogeyman, the same player who has scant regard for history and records, the Welsh wizard himself - Gareth Bale.
While playing classy football, the Old Lady of Juve struggle with speed and one only has to look at Giuseppe Rossi's hatrick in Fiorentina's demolition of Juve just five matches ago.
Juve's backline will falter from questions posed by the swiftness of the Spanish inquisition and Ronaldo will tap in the opening goal from a Bale cross.
Varane's return will solve most of manager Carlo Ancelotti's problems in defence, but expect the combative Paul Pogba to make space for Carlos Tevez to take advantage from playmaker Pirlo's precision passing.
Ronaldo will then tap in the record breaking goal in the final minutes with Arturo Vidal finally being sent off for another replay-worthy dive