The striker's absence, both from David Moyes' starting line-up and the substitutes' bench, was a major surprise and presumably due to illness or injury.
Robin van Persie was recalled, one of nine changes to the starting line-up from Saturday's 2-1 home defeat by West Brom, with David de Gea and Michael Carrick the only men to keep their places.
Meanwhile, Micah Richards was handed a surprise start by Manuel Pellegrini as Manchester City hosted holders Bayern Munich in the Champions League.
The right-back, who made only eight appearances last season and has played just one League Cup game this term, was named in the side ahead of the reliable Pablo Zabaleta.
Sergio Aguero, Jesus Navas and Gael Clichy also returned while Bayern boss Pep Guardiola chose not to play with a recognised striker after leaving Mario Mandzukic on the bench.