Freiburg went the closest to capitulating, needing extra time before getting the better of fourth-division hosts Neustrelitz.
Borussia Dortmund also looked a bit rusty against Wilhelmshaven until Kevin Grosskreutz struck 20 minutes from time. Last season's beaten Champions League finalists then went on to win 3-0.
Hoffenheim looked the most in form as they put nine goals past Aumund-Vegesack without reply, although all of the goals fell in the second half.
Heung Min Son scored his first official goal for Bayer Leverkusen in their 6-1 win at Lippstadt, with last season's Bundesliga top-scorer Stefan Kiessling also getting his name on the scoresheet.
Mainz were made to work hard for a 2-1 win at Fortuna Cologne while Wolfsburg saw off Karlsruhe 3-1 with Ivan Perisic, Diego and Marcel Schafer on the scoresheet.
There were no surprises for 2. Bundesliga sides with Kaiserslautern beating Neckarsulm 7-0, Bochum beating Bahlinger 3-1 and Aalen defeating Rosenheim 2-0.
Energie Cottbus ensured the first round of the cup continued true to form with a 1-0 win at Magdeburg with Ingolstadt beating Baumberg 4-1, meaning Osnabruck's win over Erzgebirge Aue last night remains the only minor upset of the round so far.
There are a further 13 ties to be played tomorrow before the first round is completed on Monday with four games, included holders Bayern Munich's trip to Rehden.