Hoffenheim, fighting to stay in the top flight, lead 3-1 from the home leg against the team which finished third in the second division this season.
That away goal could yet prove key at a raucous Betzenberg, but Gisdol reckons his side can handle the atmosphere.
"There's always a great vibe in the Betzenberg," he said.
"But the fans can't do anything more than scream and shout. The lads survived playing in front of frenzied spectators in both Bremen and Dortmund.
"The away goal in the first leg has left all of our senses heightened. My coaching staff and I have dealt with the issues that were present in Thursday's game. We didn't have our best day, we can improve. There are things that we can and have to do better."
Hoffenheim raced into a two-goal lead in the first leg thanks to a brace from Roberto Firmino. Mohamadou Idrissou pulled one back, but substitute Sven Schipplock gave the Bundesliga side some breathing space.
Kaiserslautern boss Franco Foda reckons he saw plenty of reasons for encouragement in that display.
"I saw in that game what was possible," he said. "The result makes me feel very confident, I am even more confident now than before the first leg.
"The away goal was very, very important. Also the players needed no lifting after the game. Every single one still believes in promotion, every one is relishing the game on Monday. It's our final, it's under floodlights, it's the Betzenberg and everything is possible."