Just a point should be enough for the visitors to hold off closest challengers Schalke, but victory would guarantee a third-placed finish.
"That has got to be our aim, to tie things up tomorrow [Saturday] so that we can then go into our remaining games against Hannover and in Hamburg in a relaxed mood," Leverkusen's top goalscorer Stefan Kiessling told the club website.
For Kiessling, the game is a return to his former club, where he launched his career in the top flight of German football.
And it also presents him with the chance to set a new record.
One goal would take him to 23 in the league this term, more than any Leverkusen player has achieved in the club's history in a single season.
Stopping him will be the key for Nuremberg if they are finally to break through the 40-point barrier this weekend.
That has been their aim for the past three games, yet they have remained stuck on 38 points.
"Now's the time to turn things around," said coach Michael Wiesinger.
"Let's not forget that before these three defeats we had gone nine games unbeaten.
"We as a team have got to give the impression that we want to forget these defeats. We want to start a positive streak of results."
Breaking 40 points is an important target for Wiesinger, who is likely to earn a new contract as soon as that milestone has been reached.
Wiesinger has an almost a fully-fit side to choose from, including Hiroshi Kiyotake, who took a knock to his knee in training, but should be available.
Daniel Carvajal is a doubt for Leverkusen after picking up an ankle problem training.