Just two points separate the sides who go into the weekend placed fourth and eighth, and with four games of the season to go, all is still to play for.
"It's going to be a very interesting weekend," said Schalke coach Jens Keller ahead of Sunday's game. "We desperately want to pick up points in the battle for fourth and, together with our fans, celebrate a win against Hamburg.
"We have got to make the most of home advantage."
To achieve that, Keller may place his faith in Klaas-Jan Huntelaar, who has been absent for six weeks due to injury, but is now back in full training.
His record of having scored four goals in his last three games against the northern Germany side make him an ideal candidate to lead the attack.
"I have been positively surprised by the physical condition Klaas-Jan Huntelaar has been in during training," said Keller at a press conference.
"There is definitely the chance that he will start against Hamburg."
His compatriot Rafael van der Vaart will be Hamburg's dangerman, although Keller has ruled out marking him man for man.
"We won't have anybody treading on his toes," he said.
Hamburg come into the game with less pressure, according to their coach Thorsten Fink.
"Schalke are under pressure because they desperately want to qualify for the Champions League," he said.
After a difficult start to the season, Hamburg's aim was never to finish inside the top four, although if the chance were to present itself, they would not turn it down.
"We want to surprise in a positive way," added Fink, whose side are one of five clubs still fighting out for three places in Europe next season.