Allofs moved from Werder Bremen to Wolfsburg last November after 13 years as Thomas Schaaf's right-hand man, following defender Naldo, who made the switch last summer, and Diego, who arrived via Juventus in 2010.
Wolfsburg's director of sport Allofs expects it to be an emotional occasion, and one which both sides will be desperate to win.
"Of course there are still lots of memories," he said. "I will meet up with a few more people than at any other away game.
"At the end of the day, there are lots of familiar faces who I worked with in recent years.
"I expect it to be an exciting game, not least because it is a northern derby, but also because our opponents find themselves in a similar situation to us.
"Neither we nor Bremen are safe yet and both clubs are in a league position they didn't really expect to be in."
Bremen coach Schaaf was keen to avoid questions about the reunion with his former colleague at the pre-match press conference.
"I am not obsessed with that," he said. "We will say hi to each other, and that will be it."
The pair were responsible for arguably the finest decade of Bremen's history with regular appearances in the Champions League, and a UEFA Cup final.
However, following Allofs' move to Wolfsburg, Schaaf does not want to dwell on the past any longer.
"I don't live in the past, but in the present and in the future," he said. "Klaus Allofs was good, great, but that's over now."
What Allofs left behind is a team who are currently playing their worse season since Schaaf took charge in May 1999 with just 32 points from 29 games.
Relegation remains a possibility, which is why victory over Allofs' Wolves would be all the sweeter for Schaaf.
"We've got to ensure we're successful again," added Schaaf. "Sooner rather than later."