Dortmund had their title taken from them last weekend by Bayern Munich and cannot move any higher than their current second place in the remaining six games of the season.
However, they are keen to finish in the top two ahead of Bayer Leverkusen and end the campaign on a high.
"We still have a lot to play for in the Bundesliga this season," said coach Jurgen Klopp.
Likewise, hosts Greuther Furth still have pride to play for even though their relegation to the second division is looking inevitable.
"Things have changed in Furth and they can play without any pressure," said Klopp. "It's going to be difficult and intensive."
One of Furth's remaining aims in this, their first Bundesliga season is to win a home match.
Thoughts of Saturday being the easiest opportunity to achieve that in view of facing an under-strength Dortmund side have been dismissed by coach Frank Kramer, however.
"Dortmund have made history with their contribution to there being two German teams in the semi-finals of the Champions League," he said.
"I don't expect we will be coming up against a weakened side. Dortmund have such a big squad anyway."
Kramer is likely to be without the injured Mergim Mavraj but goalkeeper Wolfgang Hesl is fit.
Roman Weidenfeller, Sven Bender and Lukasz Piszczek are three candidates for a rest for Dortmund as they are carrying niggling knocks, but in view of the seven changes Klopp made to his side following the first leg of their Champions League quarter-final with Malaga, they are not the only alterations to be expected.
"We're going to see how everybody looks and then we'll pick our team," said Klopp, whose side are currently six points clear of Leverkusen.