Bayern sealed the Bundesliga title with six games to spare a week ago, and followed that up by booking their place in the semi-finals of the Champions League with a 4-0 aggregate win over Italian champions Juventus.
However, Nuremberg have twice beaten Bayern after they have already won the title in the past, and Wiesinger sees no reason why they cannot do so again.
"This is a challenge which we've got to stand up to," he said. "We know where we are going and we have got to be humble about it, but we also know that we can cause them problems."
Nurnberg are one of only four Bundesliga teams to have taken any points off Bayern, thanks to a 1-1 draw in the first league meeting, and their chances of remaining unbeaten against their Bavarian rivals this season could be boosted by a possible team rotation from the hosts.
Their coach Jupp Heynckes is likely to ring the changes from Wednesday's 2-0 victory in Turin and rest key players in view of Tuesday's DFB-Pokal semi-final against Wolfsburg.
However, Wiesinger knows Bayern will still not be a pushover.
"Whoever plays, they have a lot of quality," he said. "The fact is, whoever plays will want to prove themselves.
"We just have to focus primarily on ourselves, and we've done a good job doing that in recent weeks."
Bayern's focus will still be sharp, even if they have already wrapped up the title, according to striker Mario Mandzukic.
Thoughts of taking it easy in the Bundesliga between now and the end of the season have been dismissed by the Croatian.
"We have shown that we have the quality and we want to win everything," he said.