The hosts have lost their last two games - conceding 10 in the process - and are without a win in their last four.
Gladbach are unbeaten in four and have picked up eight points in the process.
What they share is the chance of qualifying for the Europa League next season, although even there, they have contrasting ambitions.
While Freiburg coach Christian Streich does not tire of repeating that European football was never his side's goal for the season, his opposite number Lucien Favre is openly aiming for a top-six finish after getting a taste of travelling the continent this season.
"We have eight games to go and meet lots of our direct rivals (for Europe), so we need to be focused," said Favre.
"We are very positive. The second half of the season was hard to begin with and the program with European games was tough, but the team responded well in the 1-1 with Dortmund, and particularly the win in Frankfurt were good for us psychologically.
"We want to carry on picking up points and we have to play well to do that."
For Freiburg, the two-week break for internationals could not have come at a better time.
"We've conceded a fair few goals and something like that leaves its mark on you," said Streich.
"But we've had the chance to go into great detail about the defeats to Dortmund and Wolfsburg, and besides, we have no cause for concern since we are not in it up to our necks.
"In fact, we are very motivated."
The break has also allowed Streich to recover Oliver Baumann and Oliver Sorg from their respective injuries.
Gladbach defender Martin Stranzl will have to play with a mask protecting a broken nose while Juan Arango only just returned from a tiring trip to South America yesterday and his jet lag will be assessed prior to kick-off.