A 2-1 win in Munich last October remains Bayern's one and only defeat in the Bundesliga, giving Leverkusen the opportunity to complete a double at the BayArena on Saturday.
But while luck played a small part in that win inside the Allianz Arena, Leverkusen will need even more than that, claims Sami Hyypia.
"It's definitely going to be tough for us," he said. "We are going to have to show our best and give it 100% in every department.
"If we do any less than that, then we will have no chance. Bayern have such a high individual quality that they are bound to go all out and attack."
Bayern's 2-0 defeat to Arsenal in the Champions League on Wednesday and the fallout from three dismal weeks of form, according to their president Uli Hoeness, is likely to make the runaway league leaders even harder to topple.
Hyypia has had his own concerns this week, however, with a local newspaper quoting him as saying that his job would be easy if he could work autonomously.
He said: "I always thought that quotes were meant to be published as they were. I can accept that there will always be criticism, as well as praise, but not that my words get turned around."
Hyypia and Sascha Lewandowski have been in joint charge of Leverkusen for more than a full season now, and the coaching duo appear to be doing many things right with a six-point cushion over fourth-placed Schalke and the prospect of Champions League football next season.
With Hoeness' criticism ringing in their ears, Bayern will look to bounce back from what was ultimately not a costly defeat in midweek, thanks to the first-leg result.
"Overall, we have got to be very critical about this game," said coach Jupp Heynckes.
"It gave us all something to think about."
Heynckes will hope to have Franck Ribery back from injury while Bastian Schweinsteiger is available after suspension in the Champions League.
Philipp Wollscheid returns to the Leverkusen squad after suspension while Junior Fernandes is back in the country following the birth of his child in Chile.