Furth have yet to win in their own stadium since being promoted last summer, but victory tomorrow would give them two reasons to celebrate as it would also lift them above their opponents and off the foot of the table.
"It's an important game and we know we can pass bottom spot on to them, which is what we want," caretaker coach Ludwig Preis told reporters.
"This is the most important game of the season so far."
Preis has already turned around Furth's fortunes since replacing Mike Buskens just over a fortnight ago and, after securing two consecutive wins, he wants to extend his unbeaten record with a victory.
He has altered the team's mindset and they are now playing with a more attack-minded system, a tactic that resembles the system used to gain promotion last season.
And despite the stakes being so high on Saturday, he is not going to take a more cautious approach.
"We are going to go all out for the win," he said. "You have got to stick to your philosophy and keep plugging away."
The same goes for Hoffenheim, who made Bayern Munich work hard for victory last weekend, and their coach Marko Kurz does not want to see any less from his players on Saturday.
"We need to build on that performance," he said. "It would not be acceptable to do more against Bayern than against Furth."
Kurz has once again left goalkeeper Tim Wiese out of his squad due to indiscipline with Heurelho Gomes his current number one.
However, the on-loan Tottenham goalkeeper is unlikely to wear the captain's armband like he did a week ago since Andreas Beck is back from suspension, as is Eugen Polanski, but Sebastian Rudy and Sejad Salihovic are both injured.