Dortmund came through their European examination against Shakhtar Donetsk with flying colours on Tuesday, reaching the quarter-final stage for the first time in 15 years.
Schalke will be hoping to follow suit next week when they host Galatasaray and, while their focus could drift towards that match, Dortmund coach Jurgen Klopp still expects them to be fully motivated for the biggest game of the year in Gelsenkirchen.
"Schalke are back in form, back on track and they have a lot of quality," he said.
"We are going to be up against a strong Schalke side with a great deal of quality, but we're not too bad ourselves."
Klopp was particularly complimentary of Schalke's 19-year-old midfielder Julian Draxler, who will make his 100th appearance for the Royal Blues on Saturday.
"He is a fantastic lad - quick, technically strong and dangerous," sais Klopp.
"The fact he is making his 100th appearance against us is incredible. He has got everything a footballer needs, but I hope we can deal with him better than Wolfsburg did.
"We must not leave Schalke too much room because they have a very dangerous attack."
Draxler hopes to celebrate his centennial appearance with his first-ever win in a Revier derby.
"It's going to be tough because Dortmund have a great team, but we are on a par," he said. "And I have never beaten Dortmund yet."
Once the final whistle of the 142nd Revier derby blows, Schalke will then turn their attention to next week, when they may even lay the foundations for two more derbies with Dortmund this season, in the Champions League.