Robert Lewandowski serves the second of a three-game ban while Julian Schieber's red card last weekend means he too misses the short trip across North-Rhine Westphalia.
Klopp is therefore set to copy an experiment already tested by Germany coach Joachim Low and play without an out-and-out striker, but with two advanced midfielders in the form of Marco Reus and Mario Gotze, who have scored 18 goals between them this season.
"I do have alternatives," said Klopp, not wanting to reveal anything more.
Reus underlined his own goalscoring prowess with a hat-trick in the 3-0 win over Eintracht Frankfurt and Klopp would not have any qualms about fielding him in such an advanced position as he prepares to return to Monchengladbach for the first time since switching allegiances in the summer.
Reus scored 18 goals for the Foals last season, contributing in a big way to their qualifying for a place in the Europa League.
Their European campaign ended on Thursday, however, following a 2-0 defeat at Lazio.
Now, their attention turns to qualifying for the competition once again next term after getting a taste for the big midweek nights.
"Everybody wants to be involved in experiences like this," captain Martin Stranzl said.
"Of course we aim to get back into Europe.
"Borussia Dortmund at the weekend is going to be very difficult, but if you want to play in Europe, then you've got to win games like this."
Patrick Herrmann is suspended, meaning coach Lucien Favre will not be able to start with the three-man attack he deployed in Rome.