Two points separate the two sides in the Bundesliga table after Stuttgart won their first game of 2013 last weekend.
They followed that up with victory over Belgian side Genk in the Europa League on Thursday night, but despite being back in action again within 48 hours Wiesinger does not expect that to be an advantage for his side.
"It's going to be down to us to tire our opponents out," he said.
"We have every reason to be self-confident because we want to move above Stuttgart."
Stuttgart also finally have reason to be confident after back-to-back victories in the wake of a five-game losing streak in the league.
Reaching the last 16 of the Europa League for the first time in a decade should come as a welcome boost which they hope will spill over into domestic football.
"It was a great performance, particularly when you think that Genk had not lost any of their last 10 home matches," coach Bruno Labbadia said.
"My team stuck to the plan well and now we're looking forward to facing Lazio, and we go into Saturday's game even stronger."
Labbadia will have to wait until training later today to see if any of his players are carrying knocks from the European match, otherwise he is likely to name an unchanged side.
Mike Frantz is back for Nuremberg, but Wiesinger is keeping his cards close to his chest.
"We have several alternatives, particularly in attack, so we're keeping our options open," he said at a press conference.