Nurnberg picked up their first win of 2013 last weekend when they downed Borussia Monchengladbach 2-1.
Frankfurt, meanwhile, cemented fourth spot with a 2-0 road victory at Hamburg.
Armin Veh's side are now four points clear of fifth place, but Nurnberg still fancy their chances of causing an upset.
"We are going there to get something," said coach Michael Weisinger. "The Gladbach game has given us the self-confidence for it."
Weisinger says Frankfurt's current league position is no surprise, even if it may "appear to be at first glance".
"They are really strong," he added. "They have a lot of consistency."
His side's task is to break that consistency to pick up three points in their own battle against relegation.
With just eight points separating them from the bottom three, they certainly cannot afford to sit back.
Nurnberg make the trip without Timo Gebhart, who has a groin injury, but Wiesinger otherwise has a fully-fit squad to choose from.
Veh has all of his players available, but he also has his sights on four or five new arrivals in the summer as he plans for a bright future.
"I can imagine staying here," he told Sport Bild.
"We want to keep hold of the coach," added Frankfurt's chairman Heribert Bruchhagen.
"Every club would like a coach who makes the players better, and Armin Veh manages that."