With leaders Bayern Munich 11 points clear at the summit seemingly not to be deviated from their march towards the title, Leverkusen and Dortmund know the runners-up berth is the most likely prize up for grabs come the end of the season.
Leverkusen have a one-point advantage over Dortmund going into the 20th round of matches, but their coach Sami Hyypia says the defending Bundesliga champions are still a step ahead of his side.
"As a team, Dortmund are definitely ahead of us, but we are ready to do all we can to ensure our strong home form continues tomorrow," he said.
"Dortmund have a very, very good team with exceptional individual players.
"But we have shown this season that we can play well and we are going into this game to win it."
Hyypia goes into the game with a fully-fit squad to choose from.
The same cannot be said of Dortmund coach Jurgen Klopp, who is without Neven Subotic and is sweating over the fitness of striker Robert Lewandowski, who had a stomach bug this week.
However, Klopp is generally happy with his squad as crucial Champions League and DFB-Pokal fixtures approach.
"You can never have enough quality in you squad," he said.
"We have many good players, which lets me sleep well at night because we've got lots of midweek games coming up."
Klopp has not ruled out starting with Nuri Sahin alongside fellow defensive midfielder Sebastian Kehl and Ilkay Gundogan.