A win over Werder Bremen last weekend has taken Thorsten Fink's side to within a point of a qualifying berth for a place in Europe next season, and they are now keen to take the next step against fourth-placed Frankfurt.
"I know that I have a very hungry side who desperately want to win the Frankfurt game," Fink said.
"The way in which we fought back into and turned around the Bremen game certainly gives me confidence."
It is only a cautious optimism, though, since Fink acknowledges the strength of his side's opponents.
They have five points more than Hamburg and have spent the entire season inside the top four, on course for a place in the Champions League.
"Nobody expected Frankfurt, as a club promoted to the Bundesliga, to play such a strong season, but they are courageous and at the same time they have nothing to lose," Fink told a pre-match press conference.
Fink is hopeful that Marcell Jansen will return to training today after a virus while Petr Jiracek is set to make his comeback from a groin injury which has kept him out since October.
Frankfurt coach Veh does not see his side as favourites, despite the five-point advantage over their opponents.
"Just two or three players alone, like (Rafael) Van der Vaart and Jiracek are worth more than our entire budget alone," he said.
"Hamburg are an experienced side whose aim is, and has got to be, to qualify for the Europa League. They are the home team, in their own stadium, and of course they will want to win. It is going to be a tight match."