Few, that is, outside of the Rhine-Main metropolitan catchment area for which this fixture comes before any other on the Bundesliga calendar.
Frankfurt have a score to settle too. After being for many years the district's leading club, they suffered the ignominy of being pushed down the Bundesliga trapdoor by a side used to surviving in the shadows of their neighbours.
That happened in April 2011 when a 3-0 defeat at the Bruchwegstadion saw them drop into the bottom three.
Just a fortnight later, Frankfurt were in the second division.
"We took a lot of stick back then," recalled Frankfurt captain Pirmin Schwegler in Kicker magazine. "But that's a long time ago.
"We want to give it all we have got and the past no longer plays a role."
Relegation may have been a blessing in disguise for the Eagles, who reformed and regrouped and are now back in the big time, seven points above their neighbours - where they feel they rightly belong.
"To be so high up the table after 13 matches is no coincidence," said their coach Armin Veh after a 1-1 draw with Schalke at the weekend.
"We have confirmed this over a long period of time."
Now it is time for them to prove it against a side they are looking to emulate by qualifying for Europe next season, just like Mainz did against all the odds in their second year in the top flight recently.
Given how tight the league currently is, Mainz can also still aspire to a place in Europe next season with a win possibly enough to take them into the top six, and certainly enough to put a 2-1 defeat to Borussia Dortmund behind them.
"We've got to use the derby to gain revenge for an unnecessary defeat to the champions," said Elkin Soto.