Although it is the 254th time that the clubs from two cities separated by a matter of miles meet, it is only the first time that this fixture takes place in the 50-year history of the Bundesliga, and the expectations are high in both camps.
The first derby took place in 1902 with Nurnberg winning 15-0 while, eight years later, they met for the first time at the Ronhof, the scene of Saturday's historic encounter between two Bavarian rivals.
"It's the oldest derby in Germany and people are talking about it on every street corner," said Nuremberg coach Dieter Hecking to Kicker magazine.
"Even last week, nobody was interested in our game against Bayern Munich, even if that too was a derby.
"As far as the fans are concerned, the desire to win this game is enormous and we live this rivalry too."
The last time the sides met was in the DFB-Pokal last season when Furth, who were then in the second division, upset the odds by knocking Nuremberg out of the competition.
"That game makes this one even more intriguing," added Hecking.
His opposite number Mike Buskens is counting on the support of the home fans to lift them to a repeat of that win.
Furth have yet to win at home in the top flight of German football, yet their fans have not abandoned them.
"I would never have thought that possible a few years ago," said Buskens.
"The way the fans stick behind us even though we are second from the bottom of the table is extraordinary.
"Things are going more positively, even if that is not yet reflected in the league table."