Jurgen Klopp's men need to try and put their 2-1 triumph over the Spanish champions behind them and concentrate on reducing the arrears on Bundesliga leaders Bayern Munich to nine points with a win in the Black Forest.
"We want to change things in terms of the number of points we have dramatically," said Klopp, who gave his team a day off on Thursday.
"They need to free their minds. We haven't played so many terrible games this season, only the results have often not done us justice."
Freiburg coach Christian Streich did not need to watch Tuesday's Champions League match to know the size of the task in hand.
"I was not at all surprised with the way Dortmund played," he said. "It was to be expected.
"Dortmund are a team who can control a game by themselves."
However, buoyed by a first away win of the season in Wolfsburg last weekend and a run of two successive victories, Streich says his side have nothing to fear, especially on home soil.
"It's not like we are now going to start shaking," he said.
"We have played well recently. We can run, we can work and, therefore, we want to try to keep the game even at a high level for as long as possible."
Karim Guede is back in contention for a return after suspension, although Streich will have to think long and hard before making changes to a side which won two games without the forward.
Dortmund's midweek win came at a price with Mario Gotze and Sven Bender both picking up injuries.